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Would Lasix cause my Detrol LA not work as effectively?
I take 40 mg a day of Lasix and the 4 mg of Detrol LA isn’t working as effectively.
Chosen Answer:
They don’t have a direct interaction.
Lasix is a diuretic and only works on the kidneys (on a very specific site in the nephrons). It makes your kidneys dump out water and some salts.
Detrol LA is used for bladder dysfunction. There are two kinds of bladder dysfunction. Since you’re using detrol, I am assuming that you have a small, failure-to-store bladder (overactive bladder). Meaning, that your bladder is constantly contracting so it’s not able to store and hold urine. Detrol relaxes the bladder muscles so that it can hold more urine.
As you can see, the sites of action are quite different. And their metabolisms do not not effect each other (how the body chemically changes the drugs). However, since the lasix is making more urine- your bladder may/may not be able to hold it or its just full from it. If they are off-setting each other, that’s probably where its happening.
Here are some suggestions:
1. take your lasix in the morning and your detrol at night
2. Detrol LA is only taken once a day- maybe ask your doctor to try regular detrol which is taken twice a day. You may get a higher concentration with the regular release (note: detrol has lots of side effects so either read your pamphlet that came with your prescription or ask your pharmacist)
3. Place all your prescriptions/supplements/herbals in a bag and take it to your pharmacist. Ask him to look for CYP450 2D6 and 3A4 and cholinergic interactions (he’ll know what those mean). Those kinds of interactions will definitely off-set your Detrol.
4. Ask your doctor about possibly trying Ditropan (regular or XL) instead of Detrol
by: LovePharmacy
on: 22nd June 08
5 comments
Permalink1
Lasix is a diuretic and will cause you to go to the bathroom more, other then that it won’t interact with another med. You should ask your doctor or your pharmacist to make sure.
Permalink2
http://www.drugs.com and go to the section for finding interreactions to the various drugs and it will tell you what will happen taking these 2 drugs together and all other drugs and vitamins and suppliments you also take.
Permalink3
Lasix Drug Info
——————————————————————————–
Lasix Drug Uses: Lasix is a powerful diuretic. Furosemide is used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, and nephrotic syndrome. Lasix is sometimes used in conjunction with other blood pressure pills to treat high blood pressure.
How to Use Lasix: Lasix is a potent medication. Take it exactly as prescribed. Unless your doctor instructs you otherwise, drink plenty of fluids while taking Lasix. This helps your kidneys to remove the drug from your body and avoid some of the side effects. Do not stop taking this medication, even if you feel nauseated or experience vomiting. If you vomit shortly after a dose, or if you miss a dose, contact your doctor.
Lasix Precautions: Patients allergic to sulfa may also be allergic to Lasix because of a similarity in the chemical structure of the medications. Lasix should be avoided in kidney failure. Even though Lasix is important in treating excess fluid accumulation in patients with cirrhosis, sudden loss of fluid and electrolytes in these patients can worsen kidney function and even cause the patient to go into a coma. Furosemide can cause lowering of blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients already taking digoxin (Lanoxin). Please visit the digoxin (Lanoxin) site for further information.
Lasix Drug Interactions: Blood uric acid levels can increase during Lasix treatment, but precipitation of acute gout is rare. Lasix may increase the toxic effect of aminoglycoside antibiotics on the ear, especially in patients with kidney dysfunction. Furosemide reduces the kidney excretion of lithium and can lead to lithium toxicity. Lasix may impair kidney function when administered together with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Periodic blood tests are performed to monitor kidney function and electrolytes during treatment with Lasix.
Lasix Possible Side Effects: Commonly observed side effects are low blood pressure, and water and electrolyte depletion. Less common side effects include jaundice, ringing in ears (tinnitus), light sensitivity, rash, pancreatitis, nausea, abdominal pain, dizziness, anemia, and other blood disorders.
Permalink4
They don’t have a direct interaction.
Lasix is a diuretic and only works on the kidneys (on a very specific site in the nephrons). It makes your kidneys dump out water and some salts.
Detrol LA is used for bladder dysfunction. There are two kinds of bladder dysfunction. Since you’re using detrol, I am assuming that you have a small, failure-to-store bladder (overactive bladder). Meaning, that your bladder is constantly contracting so it’s not able to store and hold urine. Detrol relaxes the bladder muscles so that it can hold more urine.
As you can see, the sites of action are quite different. And their metabolisms do not not effect each other (how the body chemically changes the drugs). However, since the lasix is making more urine- your bladder may/may not be able to hold it or its just full from it. If they are off-setting each other, that’s probably where its happening.
Here are some suggestions:
1. take your lasix in the morning and your detrol at night
2. Detrol LA is only taken once a day- maybe ask your doctor to try regular detrol which is taken twice a day. You may get a higher concentration with the regular release (note: detrol has lots of side effects so either read your pamphlet that came with your prescription or ask your pharmacist)
3. Place all your prescriptions/supplements/herbals in a bag and take it to your pharmacist. Ask him to look for CYP450 2D6 and 3A4 and cholinergic interactions (he’ll know what those mean). Those kinds of interactions will definitely off-set your Detrol.
4. Ask your doctor about possibly trying Ditropan (regular or XL) instead of Detrol
Permalink5
I am not a doctor , but since Lasix,is a diuretic or water pill and Detrol LA makes you go the bathroom less, they would work against each other.